A genosensor, or gene-based biosensor/DNA biosensor, normally employs immobilized DNA probes as the recognition element and measures specific binding processes such as the formation of DNA DNA and DNA RNA hybrids, and the interactions among proteins or ligand molecules and DNA at the sensor surface.
Several enriched concepts involved in binding processes such as ribonucleotide, nucleotide, actin, and cytoskeletal protein bindings (FDR & 0.05) in our ChIP-Enrich analysis were associated with Myh7b, and those involved in transport activities and nitrogen metabolic process (FDR & 0.05) were associated with Slc22a12.
The idea of sustainable development goals, first floated by the Colombian government and seemingly gathering momentum as Rio+20 approaches, could be a way of embedding the concept into international dialogue, as well as binding together disparate processes such as Busan, Durban and the MDGs.
It should be noted that since concomitantly with the binding process other processes, such as membrane reorganization and solvation occur the dissociation constants correspond to apparent dissociation constants.
Consistent with the findings that iron is a nutritional requirement for intra-macrophage growth by F. tularensis [39], [40], [41], we identified host factors involved in iron binding and transport processes, such as cyp317a1, and tsf1, to be required for intracellular proliferation of F. tularensis.
These proteins are thought to be involved in signal transduction via calcium binding or phosphorylation/dephosphorylation in processes such as membrane expansion, lipid trafficking and OB biogenesis and mobilization [ 9, 10].
The ECM-binding integrins mediate cellular processes such as adhesion, migration, tissue invasion, and chemotaxis but also cytokine and MMP production.
Osteopontin is an integrin-binding glycophosphoprotein implicated in processes such as invasion and angiogenesis and is overexpressed in many tumour types and associated with prognosis (Bellahcene et al, 2008; Anborgh et al, 2010).
Genes in the immunoglobulin protein family also showed strong association with specific biological processes such as receptor binding, protein binding, and molecular transducer activity.
In particular, very little is known about the binding mechanisms involved in complex processes such as nucleocytoplasmic transport, where NTRs have to engage in multiple, specific binding and unbinding events while traversing a tens of nanometer thick permeability barrier.
There are currently six known human BAG family members (BAG1 to BAG6) which functionally interact with diverse binding partners and regulate important processes such as cell division and cell death.
