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Strikingly, there was no apparent distinction among the 8-mer binding preferences of any of the CSL-Notch or CSL-Notch-MAML-1 complexes examined in this study.
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A common strategy for modeling the binding preferences of a transcriptions factor is to construct a position weight matrix (PWM) from known binding sites.
Therefore, to characterize the binding preferences of a TF, we need to identify many of these potential weak binding sites and to estimate the parameters describing the statistical distribution of those sequences.
Although these motifs contain binding preferences of well-characterized TFs, most of them are novel, lacking any database matches.
Scientists leverage one step, unbiased method to characterize the binding preferences of more than 70 human RNA-binding proteins.
Martha Bulyk has taken the gene chip technology originally developed to measure gene activity and adapted it to determine the DNA binding preferences of proteins.
Here, we show that nonspecific transcription factor (TF -DNA binding significanTF -DNAluences binding preferencesignificantlyrinfluencesnscription regulators in promoter regions of the yeast genome.
Genome-wide binding preferences of the key components of eukaryotic preinitiation complex (PIC) have been recently measured at high resolution in Saccharomyces cerevisiae by Rhee and Pugh.
In particular, we reveal a highly nonrandom, statistical pattern of repetitive nucleotide triplets that correlates with the genomewide binding preferences of PIC measured by Chip-exo.
Here, we present an approach for the prediction of binding preferences of members of a large protein family for which structural information for a number of family members bound to a substrate is available.
The binding preferences of hHAsα2,6 and hHAsα2,6* (hSHand,6* and hLHAα2,6*) toward horse and swine erythrocytes were investigated.
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