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Small variations in the compound side chain length and position changed the binding preferences for individual enzymes.
Instead, we obtained informative DNA duplex stability prior by assuming different binding preferences for different TFs.
H1 binding is not sequence specific; however, it shows binding preferences for certain DNA sequences.
A list of RVDs and their binding preferences for nucleotides appears in Table 1.
C2-L1Tc may have binding preferences for specific conformations of the L1Tc RNA.
Of significant interest is the potential for this azide modification technique to assess the binding preferences of other small molecules on cellular RNAs.
We constructed the binding preference of each TF with a simple heuristic which assesses the binding preference for a TF from a set of known binding sites.
Future research goals include to develop an (unsupervised) algorithm for predicting the binding preference for TFs without prior knowledge of the known binding sites.
H. insolens EGV shows a strong binding preference for dislocations compared to the surrounding normal cell wall.
IciA also shows higher binding preference for curved DNA [16].
Our approach demonstrates binding of EWS-FLI1 to GGAA-repeat sequences in vivo and further shows a binding preference for tracts of 9 repeats or more.
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