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On the other hand Type I drugs are less selective and show binding preferences for both the open and closed forms of selected kinases.
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Instead, we obtained informative DNA duplex stability prior by assuming different binding preferences for different TFs.
The overall peptide binding preferences for the DR1201 allele were deduced by incubating these peptides in competition with the reference H1MP40 54 to determine the relative binding affinities of each to recombinant DR1201 protein.
It is reasonable to assume that a method should perform well on the single-mutant data before attempting to predict binding preferences for multi-mutant domains.
Determination of binding preferences for all 8-mers and derivation of associated DNA binding site position weight matrices were calculated using the Universal PBM Analysis Suite and the Seed-and-Wobble motif derivation algorithm [20], [31].
A position weight matrix (PWM) offers a much more precise description of the binding preferences for a given transcription factor, but the total space of all possible PWMs across each subsequence of a genome cannot be completely explored in an efficient manner.
H1 binding is not sequence specific; however, it shows binding preferences for certain DNA sequences.
A list of RVDs and their binding preferences for nucleotides appears in Table 1.
C2-L1Tc may have binding preferences for specific conformations of the L1Tc RNA.
PvNod41's binding preferences for denatured or native BSA and casein were confirmed in far western blot assays.
Small variations in the compound side chain length and position changed the binding preferences for individual enzymes.
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