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Moreover, it reveals a net binding preference towards the mir-200 family, which it antagonizes to regulate the expression of hundreds of mRNAs in the normal case.
Interestingly, PVT1 revealed a net binding preference towards the mir-200 family as the bone of contention with its rival mRNAs.
Moreover, PVT1 revealed a net binding preference towards the mir-200 family, which it antagonizes to regulate the expression of hundreds of mRNAs in the normal case.
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Interestingly, retention of I2PP2A/SET in the ER shifted its binding preference towards C16-ceramide over C18-ceramide compared to WT-I2PP2A/SET in situ (Fig 1D and E), which was independent of their relative concentrations in the ER versus nucleus; C16-ceramide was higher than C18-ceramide in both cytoplasm and nucleus (see Supporting Information Fig S4A).
Next, we investigated whether Beclin 1 ECD exhibits any binding preference towards liposomes constituted by different phospholipids.
Purified N-terminal ASPP1 and purified RAS loaded with [H]-labelled GTP or GDP were used to investigate whether ASPP1 RAD has a binding preference towards either RAS GTP or RAS GDP.
Our results distinguish three types of biological outcomes, which are discussed in the following paragraphs: We showed that switching Met binding preferences towards Src family kinases precludes axonal branching to target muscles by HGF/Met, while accommodating PI3K recruitment ensures correct peroneal nerve patterning in the hindlimb.
Significant deviation of read counts between two alleles indicates allelic binding preference for the unique TF.
We find that Gd@C82(Ohas2 han an intrinsic binding preference to the binding groove, particularly the key signature residues Y28 and W39.
For example, Fig. 5a and d explain the binding preference of the WW domain between Gd@C82(OH)22 and PRM.
It should also be noted that Hha binding exhibited no preference towards the genes up-regulated in hns/stpA and those up-regulated in both hha/ydgT and hns/stpA under the experimental conditions (compare lane 3 in panels Fig. 2C and D).
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