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Receptor binding preference is a major factor in determining host species tropism.
Its exogenous/endogenous ligand binding preference is a very active field of research in therapeutics and clinical biochemistry.
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When previous pandemic viruses were evaluated for their receptor recognition, it was demonstrated that amino-acid substitutions in HA resulting in a human receptor binding preference were a prerequisite for cross-species transmission and human adaptation of avian influenza viruses.
In the TF target gene prediction analysis, the raw DNA duplex destabilization energies were converted into probability values using a Bayesian transformation method, and each TF's binding preference is predicted with a heuristic method (see Section 2 for details).
There are, however, additional cases where the binding preference is very similar despite a low sequence identity.
The final binding preference of each TF is made by taking a vote among these six binding preferences, and again in case of a tie random binding preference is assigned.
In scaffolds e and f, the binding preference is even more pronounced (see Fig. 2B): cluster e seems to be rather P-gp selective, while cluster f shows a rather BCRP selective pharmacological profile.
This binding preference is thought to be commensurate with the role of HU in DNA inversion [22].
This method not only reduces the PSSM model redundancy, but also offers models for the transcription factors for which the binding preference is currently unknown (since the transcription factors with unknown preferences are likely to belong in one of the existing families).
However, for different antibody (ERα and Pol-II), the binding preference is totally different.
We next asked whether the observed Pellino2 peptide binding preference is also seen for the other Pellinos.
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