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In contrast, similar compounds containing bicyclic aromatic rings such as adenine and guanine derivatives do not bind to MA0940, indicating that this gene product has a binding preference for the dimethylbenzimidazole moiety and supporting the assignment of its function as alpha-ribazole-5'-phosphate phosphatase.
Cdc5-D3 alone binds directly to all of the RNAs in the assay, with a significant binding preference for the U6-ISL.
And the most superiority of P1 was the good binding preference for the G-quadruplex than the duplex DNA.
However, compared to H-pin 3e, tetraamide H-pin 5 demonstrated superior binding preference for the cognate sequence over its non-cognates, ACCGGT and AAATTT.
This also suggests that di-peptides are fairly promiscuous protein surface binders and may not offer a specific binding preference for the dimer interface site had the docking site definition been larger.
Emission of the studied 6,6′-disubstited dyes in DNA presence is considerably more intensive than in presence of RNA, that points on the existing of DNA binding preference for the mentioned dyes.
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The overall peptide binding preferences for the DR1201 allele were deduced by incubating these peptides in competition with the reference H1MP40 54 to determine the relative binding affinities of each to recombinant DR1201 protein.
Interestingly, OGG1 and NEIL1 displayed different binding preferences for the two TS mimics, suggesting alternate modes of recognition and catalysis for these bifunctional glycosylases.
This variability of the ligands may determine the binding preference for distinct members of the CEA family which represents one mechanism that may determine tissue tropism (Virji et al., 1999; Bos et al., 2002; Gray-Owen, 2003; Hauck and Meyer, 2003; de Jonge et al., 2003).
Indeed, Numb exhibited distinct binding preference for components of the Par3 Par6 aPKC complex in both ts-src-MDCKI and MDCKII cells, depending on the status of Src activation.
Ephs are a large family of tyrosine kinase receptors and are subclassed into EphAs and EphBs, depending on their extracellular sequence homology and binding preference for their ligands, the membrane-bound ephrins (Pasquale, 2004).
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