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In line with these experimental results, the GABA-A receptor binding potential was reduced in the patient's amygdala/hippocampus complex.
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Could that potential be reduced?
The PET scan analysis showing reduced 11C-FMZ binding potential in motor-premotor cortex was now extended and we show that the binding potential was also reduced in the limbic region, namely the amygdala and hippocampal complex (Figure 1; right: 1.80 vs. 2.18±0.39, left: 1.58 vs. 1.96±0.41, SPS patient vs. control patients, means ± SD).
Consistent with these findings, the relative CRE-, and more importantly, VEGF-luciferase reporter gene activities, a functional measure of the CREB-DNA binding potential, were also reduced in this disease state (Fig. 3Db,c).
In the s.c. xenografts, the binding potential was higher peripherally than centrally.
[11C]NNC 112 binding potential was measured with kinetic analysis using the arterial input function.
The potential at the binding pocket was reduced with acetylation of only Lys23, suggesting that acetylation specifically at this site could affect ADP binding affinity.
In addition, serotonin (5HT) transporter binding appears to be reduced in certain brain regions known to play an important role in social cognition and behavior [ 37], and 5HT binding potential is negatively correlated with social impairment.
When 85 B was boiled, antigen binding was reduced.
Lamin A/C binding on muscle genes was reduced and differentiation potential was enhanced on treatment of myoblasts with a histone deacetylase inhibitor.
The positive zeta potential value of fGO, upon binding with the negatively charged pDNA, was reduced.
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