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Although AacC2c1 lacks a PAM-interacting domain, our analysis revealed that the PAM duplex has a similar binding position found in Cpf1.
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Likewise, six start binding positions found conserved across hundred of glycoprotein genes.
Analysis of the trajectories shows that the crystallographic binding position was found in two out of the three simulations after 81 and 690 ns simulation time (drop of red and green lines in Fig. 3b), respectively.
NET-specific binding was found in the locus coeruleus.
In EF3, two positions typically occupied by a negatively charged D host an A and a P, whereas no residue promoting calcium binding is found in EF4.
However, in yeast similar sequences to the binding site are found in the equivalent positions.
The results of this analysis including positions and sequences of the corresponding binding sites are given in Additional file 7. Altogether, 368 putative binding sites were found in 220 different promoters.
The results of these analyses including positions and sequences of the corresponding binding sites are given in Additional file 3. Altogether, 110 different c-Myc binding sites were found in 94 different promoters, which partly were recognized by different matrices.
The presence of a cysteine in this position as found in EphB3 is likely to result in a steric clash with the solubilizing group, the position of which is constrained by the planar hinge binding group.
Metallic bonding is another type of binding found in condensed matter.
The LDL-R binding site (LRKMRKRLLR) was found in positions 137 146 of the mature protein.
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