Sentence examples similar to binding pockets that we from inspiring English sources

The ALDHs are known to have variable conformations between non-homologous proteins just like the ligand molecules, but it is also possible that the shapes of different protein binding pockets that bind the same ligand vary [31].

Here, we investigate protein binding pockets that accommodate extruded nucleotides not involved in RNA base pairing.

Herein we describe the identification of novel binding pockets that may provide an opportunity for the design of mutant selective inhibitors.

Here we present the selection of potential ligand binding pockets that occur during molecular dynamics (MD) simulations of a homology-based receptor model.

Alternatively, the inorganic phosphate may occupy binding pockets that are normally occupied by the phosphate moieties of NADP+ during catalysis, thereby stabilizing the enzyme.

Examples are presented illustrating the close proximity of some indels to established small-molecule binding pockets that can potentially facilitate selective targeting to the parasites and bypassing their host, thus reducing or eliminating the toxicity of the potential drugs.

DC-SIGN forms tetramers with four binding pockets that have higher affinity for glycoproteins such as HIV gp120 than monomeric DC-SIGN [26].

Comparison of these structures with the CKI-7-bound casein kinase 1 reveals features in the binding pockets that are distinct in the bacterial kinases and could be exploited for the design of a bacterial kinase specific inhibitor.

As a consequence, BRD acetyl-lysine binding sites are deep and largely hydrophobic binding pockets that represent attractive targeting sites for the development of Kac competitive inhibitors.

The structure of survivin does not reveal hydrophobic binding pockets that could serve as docking sites for low molecular-weight ligands.

(2011) established a method to construct the structural signatures for enzyme binding pockets that require high-quality, manually curated enzyme binding sites and is, therefore, not suitable for high-throughput studies.