Sentence examples for binding pockets responsible for from inspiring English sources
The predicted binding pockets responsible for amino acid selection and activation were found within this region in both cases.
Using nuclear magnetic resonance (NMR) spectroscopy, stopped-flow kinetics, and isothermal titration calorimetry, we show that recoverin populates a minor conformation in solution that exposes a hydrophobic binding pocket responsible for binding rhodopsin kinase.
BH3 and BH1, primarily located on alpha helices α2 and α5, make up the BH3 binding pocket responsible for binding Bak [ 37].
Mutations of HIV protease at Val32, Ile50 and Ile84 (hydrophobic residues, close to binding pocket) are responsible for the resistance to most FDA approved drugs due to loss of Vander Waal interactions [5].
PX domains contain a triple-stranded antiparallel β-sheet followed by a helical subdomain made up of four α-helices, with the β1 and β2 loops together with α-helix 3 forming a positively-charged pocket responsible for binding phosphoinositides (Bravo et al., 2001).
In particular, A601 and A602 localize in IIIB subdomain, in a pocket responsible for fatty acids and thyroxine binding.
A highly conserved asparagine residue in this binding pocket is typically responsible for anchoring the acetyl-lysine side chain via hydrogen bonding, but can in some cases be replaced by other amino acids, including threonine or tyrosine [ 1].
The same four binding pockets were found for dasatinib as for the above PP1 (Additional file 2: Table S17).
Li et al. [12] also investigated the effect of the binding pocket hydrophobicity and reported that the performance of Glide and Surflex is better for indisputably hydrophobic or hydrophilic binding pockets than for pockets with intermediate hydrophobicity, while Gold tends to perform better on only hydrophobic pockets.
The dataset was used to develop virtual binding pockets for accommodating HLA-II specific sHLA-II specific
The binding pockets for HT ligand binding are indicated by orange arrows.
