Sentence examples for binding pockets on the from inspiring English sources

This study revealed that small ligands bind almost exclusively to well-defined binding pockets on the protein surface, independent of their affinity.

Our virtual ligand concept uses the PocketPicker [21], [22] algorithm to calculate a discrete representation of one or more potential ligand binding pockets on the surface of a 3D protein model.

Here, we present two new algorithms for designing tailored ligand binding pockets on the protein surface that account for backbone and side chain flexibility.

Various Ang II-AT1 receptor antagonist drugs are available in the market as antihypertensive drug, so we have performed docking study with the binding site prediction algorithms to predict different binding pockets on the modeled proteins.

Two binding pockets on the ΔF508-NBD1 ΔF508-NBD1

Of the 10 minimotif groups, many used different binding pockets on the SH3 domain.

For example, added to norovirus-like particles, citrate precisely binds at the binding pocket on the histo-blood group antigens involved in attaching to host ligands, preventing the transmission of these viruses, as well as reducing symptoms in those already infected with noroviruses [28].

The guanine nucleotide binding pocket, on the other hand, is composed of at least ten residues; however, one arginine residue (R580) interacts with the guanine nucleotide at several points and its mutation to alanine (R580A) results in the almost complete loss of guanine nucleotide binding activity without any significant effect on the transamidating activity [20], [22].

The FBP binding pocket on the C-C′ interface of PKM2K305Q are structurally similar to that of PKM2Oxalate.

FBP could recruit the FAM to the FBP binding pocket on the C-C′ interface and facilitate R-state tetramer formation of PKM2.

The molecular design was performed to predict the binding mode of the most promising compounds 4, 10 and 12 with the active site of hCA IX, that showed appropriate fitting with the relevant amino acids in the binding pocket on the basis of standard bond lengths, angles, S score and E conformation data.