Sentence examples for binding pockets for small from inspiring English sources

Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (SADH) reduces aliphatic ketones according to Prelog's Rule, with binding pockets for small and large substituents.

The three-dimensional structure of Rsd in complex with σ70 region 4 reveals that the sigma-binding surface is connected to exposed cavities, which might act as binding pockets for small regulatory molecules.

We analysed the two potential binding pockets for small molecules using SiteMap (Schrödinger) which takes into account the volume of the pocket, degree of enclosure and degree of hydrophobicity.

Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA, which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF inhibitors.

In the case of VP30, a potential binding pocket for small-molecule inhibitors has been suggested by Hartlieb et al. (2007).

With this exploration under way, it is not difficult to confirm that the INSR dimerization creates a good binding pocket for the small INS peptide, which upon binding further activates the nearby Tyr kinase autophosphorylation, therefore triggering a cascade of signalling events in cells [ 52].

Nevertheless, the binding pockets for these flexible loops are often also dynamic and thus are more likely to accommodate small molecules either from a fragment-based approach or from a library of peptide mimetics.

The binding pockets for HT ligand binding are indicated by orange arrows.

In contrast, mSAA3 is α-helical and oligomerizes to form a hollow, largely non-polar interior that could serve as a binding pocket for a non-polar small molecule.

Inspection of the molecular model of trypsin with Z-Gly-O3G revealed that there is space in the binding pocket for the introduction of a small substituent, such as a methylene (O3G=) or two fluorides (O3GF2), which are weak and strong inductively electron-withdrawing groups, respectively.

This suggests that the binding pocket for the C-2 alkyl substituent in Ch-MAL is designed to bind small alkyl chains and excludes large groups.