Sentence examples for binding pockets at the from inspiring English sources
The blue spheres are Ca2+ in the binding pockets at the PS-binding side of anxA5.
A virtual screening strategy that included per-residue interaction patterns (footprints) was employed to identify small molecules compatible with putative binding pockets at the internal interface of the NHR helices at the core native viral six-helix bundle.
A comparison shows that the crystal structures of FabG from P. aeruginosa and S. aureus 33) are very similar and that the inhibitor binding pockets at the A/B and C/D interfaces (see below) could potentially also be formed in the S. aureus enzyme.
According to accepted theory, an increase in cytosolic Ca2+ concentration causes four calcium ions to bind to calmodulin, which allows calmodulin to enter the binding pocket at the MLCK C-terminus, and thereby, activates MLCK [35].
By deriving a virtual binding pocket at the same time as the relative poses of ligands are identified, the key analogy is that one can treat a computational model of a binding site as one treats a protein binding pocket.
Three classes of positive modulator, the benzamides, the thiadiazides, and the biarylsulfonamides differentially occupy a solvent accessible binding pocket at the interface between the two subunits that form the AMPA receptor ligand-binding pocket.
Another parameter to consider is the size of the binding pocket at the target receptor; searches are usually performed to find fragments that can bind to a small particular area of the binding site at the target receptor, in that case, a user-defined ligand is needed for that purpose.
This result is consistent with previous reports that RB interacts with E2F3 mostly through its E2F-peptide binding pocket at the A/B interface that is inactivated by the K530A mutation.
Unlike the structure of PptT described here, HsPPT contains a C-terminal loop-helix motif that abuts the CoA binding pocket at the CP binding interface.
These observations are consistent with the hypothesis that EtOH inhibits L1 adhesion by interacting with an alcohol binding pocket at the Ig1 Ig4 interface of the L1-ECD (Arevalo et al., 2008; Dou et al., 2011).
