Sentence examples for binding pockets around the from inspiring English sources
As the authors assume this can not happen in the reported reaction due to a mandatory anchoring of the substrate's carboxylic group by one of the two binding pockets around the PLP-lysine Schiff base (the external aldimine intermediate) which is certainly not possible with the esterified substrate (Kim et al. 2007).
Part of the Y-shaped active-site cavity observed in the unliganded enzyme constricts in complex II and forms a tighter binding pocket around the hydrophilic portion of the product.
The acetate derivative 23 was synthesized in order to probe the flexibility of the binding pocket around Gly205 and Asp161, which form hydrogen bonds with the amino group of compound 11 in the binding mode determined by crystallography.
In the case when a compound hits closely related protein targets, it might be due to the significant similarities among the protein target sequences, or due to the highly conserved 3D structures around the binding pockets of the target proteins.
The blue spheres are Ca2+ in the binding pockets at the PS-binding side of anxA5.
Two binding pockets on the ΔF508-NBD1 ΔF508-NBD1
The expected source behind such an entropy increase is the release of the water molecules from the binding pocket and from around the ligand to get more freedom in the bulk phase.
This portion of the retinal-binding pocket around helices III and VI appears to be held rigidly together by tight van der Waals interactions [32].
It takes averagely 1 3 minutes for binding sites detection, and the potential binding sites can be interactively viewed and downloaded in PDB files for off-line analysis, which includes the binding pocket surface, the residues around the site, and key features of the pharmacophore model derived from the site.
Upon ligand binding, solvent molecules around the binding pocket and the ligand become displaced or rearranged.
Alanine scanning of the active-site residues shows that both the catalytic lysine and the residues around the binding pocket for the substrate naphthyl group make critical contributions to catalysis.
