Sentence examples for binding pocket within the from inspiring English sources
Recently, SMLs (small-molecule ligands) have been identified, which bind in an allosteric binding pocket within the transmembrane domain.
Imatinib binds directly to the ATP binding pocket within the kinase, preventing its activity, and thereby causing tumor cell death.
The side chain of H3K27me3 inserts into a deep binding pocket within the active site cleft (Fig. 2d).
The compact β-hairpin binding pocket within the immunity protein represents a tractable system for the rationale design of small molecules to block CdiA-CT/CdiI complex formation.
Recently, the interaction site of Syt I and Syt-II was located near the ganglioside binding pocket within the Hcc-domain of BoNT/B and G. Furthermore, the BoNT/B Syt II interaction could be characterised at the atomic level.
Three series of 3-aminopropionic acids containing, N-, α-, and β-substituents, were designed and synthesized to probe the position and the size of a lipophilic binding pocket within the proposed pharmacophore.
The Site Finder module of MOE 2008.10 was used to identify the possible substrate binding pockets within the newly generated 3D structure of the hTLR10/1, hTLR10/2 hetero and hTLR10 homodimers.
Interestingly, I28A also showed outliers at S58, V62, and C113, which are part of the substrate proline binding pockets within the PPIase domain.
In solution, on the other hand, two of the crystallographic CRs left their binding pockets within the first 15 ns of simulation, while the other two showed increased molecular motion and low occupancy (Supporting Information, Table S5, Figure S8 a).
The ATP-binding pocket within the KD serves as a well-defined target site that may allow one to achieve the complete annihilation of the kinase's catalytic activity.
Our findings also predict that there will be a ubiquitinPhospho−Ser65-binding pocket within the catalytic core of Parkin that would induce a conformational change to activate Parkin following the ubiquitinPhospho−Ser65 interaction.
