Sentence examples for binding pocket which has from inspiring English sources

FhGAPDH lacks a binding pocket which has been exploited in the design of novel antitrypanosomal compounds.

Subsequent biochemical experiments revealed that specificity of ligand recognition can be affected by point mutations outside of the binding pocket, which has implications for both the assignment and reengineering of riboswitches in this structural class.

In the N-terminal portion, α-sarcoglycan has a cadherin-like domain and Ca2+-binding pockets, which have also been described in α-dystroglycan, suggesting a possible Ca2+-dependent heterotypic adhesion between the two proteins (Ref. 76).

The kinase domain has a broad substrate binding pocket, which preferentially recognizes double-stranded substrates with recessed 5′ termini.

The PH domain of Son of sevenless (SOS) and PX domains of p47phox have previously been shown to possess a phosphoinositide-binding pocket and a second anion binding pocket which enables them to interact with PA facilitating plasma membrane recruitment [40], [41].

One approach is to identify molecules that occupy the pterin binding pocket which is distinct from the pABA binding pocket that binds sulfonamides.

Microcystis aeruginosa NPLJ-4 and Microcystis sp. RST 9501 have identical predicted binding pockets, which differ by three amino acids at positions 301, 330, and 331 in comparison to strains that activate L-Ala (Table  2).

In comparison with the S5 S1 pockets, the prime-side binding pockets, which interact with the P′ residues downstream of the cleavage junction, are less well defined.

Both enzymes are traversed by a DNA-binding groove connecting to a uracil-binding pocket, which in the case of MUG is less tailor-made for uracil.

Electron density indicates phospholipid bound within the ligand-binding pocket, which we confirm using mass spectrometry of solvent-extracted samples.

In general, GR has proven to be a flexible enzyme capable of binding a variety of small molecules both in the active site and at allosteric binding pockets, some of which have included cyclic substrate-product analogues.