Sentence examples for binding pocket which determines from inspiring English sources

High structural conservation of the adenylation domain allows prediction of amino acids lining the putative binding pocket which determines substrate specificity [ 20].

One approach is to identify molecules that occupy the pterin binding pocket which is distinct from the pABA binding pocket that binds sulfonamides.

FhGAPDH lacks a binding pocket which has been exploited in the design of novel antitrypanosomal compounds.

The kinase domain has a broad substrate binding pocket, which preferentially recognizes double-stranded substrates with recessed 5′ termini.

Majority of small molecule kinase inhibitors reversibly occupy the ATP binding pocket, which means that they are ATP-competitive inhibitors.

In comparison with the S5 S1 pockets, the prime-side binding pockets, which interact with the P′ residues downstream of the cleavage junction, are less well defined.

The selectivity of proteasome inhibitors is determined by the geometry and amino acid side chain properties of the substrate-binding pocket, which differs between the three catalytic beta subunits (Groll et al, 2006).

Both enzymes are traversed by a DNA-binding groove connecting to a uracil-binding pocket, which in the case of MUG is less tailor-made for uracil.

Electron density indicates phospholipid bound within the ligand-binding pocket, which we confirm using mass spectrometry of solvent-extracted samples.

Such conformational changes facilitate the formation of an ephrin-binding pocket which accommodates a phenylalanine residue, Phe120ephrinB2.

Additionally, the SRL is proposed to host several cation-binding pockets, which could facilitate platinum coordination.