Sentence examples for binding pocket was not from inspiring English sources
Although the native ligand binding pocket was not or not fully open in the unbound crystal structure, PocketScanner and PocketBuilder successfully generated conformations with pockets into which the known inhibitors could be docked in orientations similar to those seen in the inhibitor bound crystal structures.
We suggest that when KA is bound strongly in the active site, the binding pocket is not accessible to substrate molecules, subsequently TyrBm is not active.
If the compounds of a data set are structurally too similar, the finding of entirely different scaffolds for the same binding pocket is not to be expected.
The discovery of imidazole in the binding pocket is not surprising as imidazole, which is used in QacR affinity purification and aids in its solubility, is an aromatic cation mimic and thus similar to most of the known QacR ligands.
The similarity between the drug affinities of the mutant and wt QacR proteins for all of the drugs tested here points towards the conclusion that at least for QacR, individual electrostatic interactions between a drug and a proximal "neutralizing" glutamate in the binding pocket are not major contributors to binding affinity.
This fourth site can be classified as a cryptic site because the binding pocket is not apparent in the apo structure at either room- or cryogenic temperature.
The binding pocket is not in very close contact with the dimerization interface and only a few side chains project into the joint neighborhood.
Collectively, these data suggest that the involvement of acidic residues E57 and E58 in the QacR multidrug binding pocket is not absolutely required for the neutralization or binding affinity of either cationic drug Be or Dq.
As the Egf receptor ligand binding pocket is not well conserved between tetrapods and teleosts, the use of heterologous ligand to activate fish Egfr may differ and could hamper or event prevent the biological output.
