Sentence examples for binding pocket that is from inspiring English sources

A binding pocket that is likely to bind a ligand will have an Sscore greater than 0.8 and a Dscore greater than 0.83 [44] 44].

Consequently, they form a characteristic "glove" shape, encompassing a hydrophobic binding pocket that is able to bind specific small organic molecules [4].

One obvious common feature of these two groups of GT41 proteins is that both bind sugars donors that are activated by UDP, requiring a binding pocket that is formed by the C-terminal half of the GT-B domain (Fig. 1A) [18], [18].

The relatively smaller OPR3 residues allow formation of a wider substrate binding pocket that is less enantio-restrictive.

By contrast, Dou and co-workers have designed a β-barrel that has a shape distinct from those found in nature, and constructed a binding pocket that is specifically tailored to a target small molecule.

The structure of NPC1L1 NTD), while sharing the same overall topology as NPC1 NTD), reveals a cholesterol binding pocket that is closed from solvent, suggesting a gating mechanism that relies on the movement of multiple elements around the cholesterol entrance.

HSP70 has a binding pocket that was first demonstrated for the ER HSP70 homolog BiP [ 70] and later for bacterial HSP70 [ 71].

The authors proposed a molecular model explaining the interaction with key amino acids of the putative binding pocket that were identified in functional studies.

Despite the retention of the multisite binding mechanism in the mutants, functional manifestations reveal an exquisite sensitivity to even minor structural changes in the binding pocket that are introduced by conservative substitutions such as I369F, I369L, and A370V.

Here, we report the development of a versatile alternative FRET sensor containing a de novo Cys2His2 binding pocket that was created on the surface of the donor and acceptor fluorescent domains.

The strong photoregulation by MAB-0 suggests a favorable interaction between its ligand moiety and the GABA-binding pocket that is specific for the trans configuration.