Sentence examples for binding pocket that could from inspiring English sources
Leapfrog was able to locate a previously unrecognized binding pocket that could accommodate these otherwise anomalous regions of structure.
The structure of survivin does not reveal hydrophobic binding pockets that could serve as docking sites for low molecular-weight ligands.
Our results suggest novel mechanisms of PTPA in PP2A activation with structural economy and a unique ATP-binding pocket that could potentially serve as a specific therapeutic target.
The available structures of A3A and four other APOBECs [ 44– 48] show no obvious features within the C- or mC-binding pocket that could explain the observed difference in mC deamination activity of A3A, A3BCD2 and other APOBECs.
One approach is to identify molecules that occupy the pterin binding pocket which is distinct from the pABA binding pocket that binds sulfonamides.
Terry et al. have shown that by mutating the tryptophan at 102β to a threonine and the tyrosine at 361β to a phenylalanine, which was also observed from an overlay of the binding pockets, that PFTase could employ GGPP as a substrate.
Here, we investigate protein binding pockets that accommodate extruded nucleotides not involved in RNA base pairing.
Consistent with this, the protective hydrophobic "lid" of the aminoacyl-binding pocket of aSelB that could protect selenocysteine/cysteine from oxidation also appears to be present in aSelBL.
In the model based on the mouse structure, these residues are found to be facing the drug-binding pocket while residues that could be rescued with cyclosporine A (positions 295, 298, 302, 305, and 309) face the lipid environment.
Upon inspection of the Parkin structure, we identified two further putative phospho-Ser-binding pockets that we term "Pocket 2" and "Pocket 3" (Fig 2A).
Superimposing D3 onto TFMPV-E2 and then minimizing the ERα binding pocket suggests that ERα could potentially accommodate D3 in an agonist-type binding mode similar to that when TFMPV-E2 is bound.
