Sentence examples for binding pocket that allows from inspiring English sources

ERs have a large and flexible binding pocket that allows for multiple ligands to bind, including steroids, phytoestrogens, and xenobiotics.

The internal receptor is unexpected in that it is located between the transmembrane helices of KcsA and consists of a hydrophobic binding pocket that allows direct communication between the aqueous cavity of the channel and the lipid bilayer, reminiscent of the fenestration observed in bacterial sodium channel structures.

The HSP90 homologue gp96 also contains a binding pocket and, like HSP90, it is an open binding pocket that should allow peptides of any length to interact with it, though the presence of a disulphide bond in this domain may also affect peptide binding [ 75].

One approach is to identify molecules that occupy the pterin binding pocket which is distinct from the pABA binding pocket that binds sulfonamides.

The relatively smaller OPR3 residues allow formation of a wider substrate binding pocket that is less enantio-restrictive.

The Erh1 binding pocket that mediates binding to Mmi1Trp112 was also nearly identical between S. pombe Erh1 and human ERH (Supplementary Fig. 3b, c).

Here, we investigate protein binding pockets that accommodate extruded nucleotides not involved in RNA base pairing.

Mutation of one or more of these residues generates a "pocket" in the ATP binding site that allows the mutant kinase, but not other cellular kinases, to utilize analogs of ATP with bulky substituents synthesized onto the N-6 position.

Ligand binding induces a conformational change of the AF-2 region that allows dissociation of accessory proteins, exposure of the DNA-binding pocket and recruitment of coactivators [19].

In the wild-type GltA structure, histidine-110 adopts an upward conformation that allows for accommodation of NADH in the binding pocket.

14, 15 Etravirine has a diarylpyrimidine-based structure with molecular flexibility that allows it to accommodate to mutational changes in the RT binding pocket.