Sentence examples for binding pocket surrounded by from inspiring English sources
Especially, we observe a potential substrate binding pocket surrounded by hydrophobic residues upon NADPH binding and present evidences that this pocket is essential for BdcA binding NADPH and exerting its biological functions.
Overall, the sulfonamide moiety of K-8794 ispecificallyly recognized by the positively charged residues of the ETB receptor, and the other moieties fill the space within the transmembrane binding pocket surrounded by TM2 7 and facilitate the interactions with the receptor.
The binding pocket surrounding this group is negatively charged (mainly due to D31 of HC CDR1 and D52 of HC CDR2; Fig. 2 D ), which is shown by calculation of surface electrostatics using the Fab structure without biocytinamide.
In structurally characterised phosphoinositide-binding domains, a similar arrangement is observed, with a pocket surrounded by basic residues, interacting with the phosphate groups (Lemmon, 2003).
In the endo binding mode the N2 is nestled within a binding pocket capped by the side-chain of α-70Val; in the exo mode, the N2 is pointed to a pocket surrounded by α-191Gln and the homocitrate ligand of Mo.
The isatin scaffold is oriented in the hydrophobic pocket surrounded by the side chains of Leu16, Phe21, Leu80 and Leu116.
Our results from structural modeling and evolutionary analyses of functional residues point to key fragments within the binding pocket which surround and connect the α-helix and β-strand structural elements of the pocket, as general regions important for specificity.
However, our survey site is a backland located behind a pocket beach surrounded by rocky cliffs (Fig. 2a).
Fig. 1 LEH binding pocket harboring substrate 1 surrounded by 8 CAST residues which are grouped into two 4-residue randomization sites 1 (green) and 2 (cyan).
The ligand-binding pocket is surrounded with mostly hydrophobic residues.
