Sentence examples for binding pocket such that from inspiring English sources

Strikingly, in this complex, Be reorients in the multidrug binding pocket such that the positive charge centered on N1 of Be is no longer immediately complemented by either E57 or E58, or indeed by any other acidic residue.

Specifically, Dq spans the length of the multidrug-binding pocket such that one aminomethylquinolinium group remains sandwiched between the aromatic side chains of residues W61 and Y93 in the R6G sub-pocket, and the other between F162' (where prime indicates the second subunit of the dimer) and Y103 in the Et sub-pocket.

Another mechanism underlying imatinib resistance is point mutations in the BCR-ABL gene altering the conformation of the ATP-binding pocket such that imatinib no longer has affinity.

This mutation alters the specificity of the ATP-binding pocket such that the affinity for ATP is greatly increased, thereby interfering with the ability of drugs to compete for binding to the receptor [94].

Additionally, substrate binding may be prevented by conformational changes that occlude the substrate binding pocket, such as movement of loop residues 14 27 in KSHV Pr.

Thus, the I123L and L146F changes may shift the position of the two helices relative to each other and thus alter the size and structure of the associated binding pocket in such a way that it becomes inaccessible for the CD3ζ chain but still accommodates the cytoplasmic domain of CD4, which binds the same hydrophobic crevice (Grzesiek et al., 1996).

Despite the retention of the multisite binding mechanism in the mutants, functional manifestations reveal an exquisite sensitivity to even minor structural changes in the binding pocket that are introduced by conservative substitutions such as I369F, I369L, and A370V.

The Erh1 binding pocket that mediates binding to Mmi1Trp112 was also nearly identical between S. pombe Erh1 and human ERH (Supplementary Fig. 3b, c).

The mSAA3 tetramer forms a hollow hydrophobic binding pocket that can accommodate retinol.

DC-SIGN forms tetramers with four binding pockets that have higher affinity for glycoproteins such as HIV gp120 than monomeric DC-SIGN [26].

Here we detail the mutagenesis strategy for the ATP binding pocket of Raf-1, such that it can utilise an N6-substituted ATP analogue.