Sentence examples for binding pocket should be from inspiring English sources
Based on this receptor design, it was recognized that the binding pocket should be suitable to a variety of guests possessing either (or both) positive and negative charges.
While this experiment has not been carried out for all of the hits, we assume that they also bind the same surface based on their similar structures and the fact that compounds that bind outside of the antigen-binding pocket should have been removed from the population in the prescreen in which the beads were exposed to an IgY population that did not contain anti-ADP3 antibodies.
Hence, although most protein deposits share a repetitive cross-β sheet structure, possible differences in the binding pocket microenvironments should be considered when designing ligands towards distinct protein aggregates.
Evolutionary tracing of the proposed drug targets has been done with a viewpoint that the amino-acids lining the drug binding pocket should have a lower evolvability.
Hypothetically, decreasing the size of the nucleophile binding pocket should increase the enantioselectivity of the enzyme with smaller secondary alcohols.
This implies that the NADPH-binding pocket should accommodate alternate binding modes of the coenzyme.
The use of "alternative pockets" represents a new mode of high affinity peptide binding, that should be considered when predicting peptide epitopes for MHC class I.
In summary, these findings demonstrate that RTP binds in the cap-binding site but also suggests new features of this pocket that should be considered in drug design efforts and reveal new insights into ligand eIF4E recognition.
Replacement of water from the uncomplexed binding pocket is assumed to be entropically favorable.
In order to delineate the precise role of the acidic residues within the QacR multidrug-binding pocket in ligand binding and induction, each should be substituted with uncharged side chains, e.g., by alanine or isosterically by glutamine and biochemically and structurally characterized.
