Sentence examples for binding pocket provided by from inspiring English sources
In our structure, we clearly observed the metal binding pocket provided by the buried surface between the N-terminal and C-terminal domains (Fig. 5B).
Among other identified amino acid substitutions, position Gly165 in the S1 binding pocket provided insights in subtilisin Carlsberg's promiscuity by promoting ester perhydrolysis.
Switching agonism to antagonism and the reverse by changing either SMLs or residues covering the binding pocket provides detailed knowledge about discriminative pharmacophores.
Molecular modeling of TIQ-10 into the binding pocket provides a pose consistent with STDD-derived interactions.
The "flipping" of damaged nucleotides out of the DNA helix and into active site binding pockets provides a mechanism by which glycosylases interact with damaged DNA (for a review, see ref (50)).
These drastic changes in measured TIF likely occur from slight changes in the binding pocket caused by different co-binding peptides P1, P2, and P3.
Especially, we observe a potential substrate binding pocket surrounded by hydrophobic residues upon NADPH binding and present evidences that this pocket is essential for BdcA binding NADPH and exerting its biological functions.
Modeling showed that the Cys4 binding pocket created by displaying cysteines on a β-barrel scaffold in these variants was too large to allow simultaneous coordination of Zn2+ by all four cysteines and suggested that a binding site consisting of a combination of cysteines and histidines might provide a better Zn2+ binding site.
Docking models are frequently inaccurate due to many simplifications used in their implementation, whereas MD simulations can provide considerably more accurate data as to the location of a ligand in a binding pocket by refining initial docking structures (22, 23).
