Sentence examples for binding pocket of these from inspiring English sources

A conserved YXXXY motif in the heme binding pocket of these NEAT domains, where one tyrosine binds the iron and the other tyrosine is involved in hydrogen-bonding to the axial tyrosine, appears to be key for heme binding, as other NEAT domains lacking this motif do not bind heme.

These compounds have two independent reactive centers and were designed to function as dual irreversible inhibitors of the kinase domains of both Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) where each reactive center targets a different, non-conserved, cysteine residue located in the ATP binding pocket of these enzymes.

Sunitinib is a multitargeted receptor tyrosine kinase inhibitor of VEGF receptors, among others, which interacts with the ATP binding pocket of these kinases and acts as competitive inhibitor with ATP.

The molecular docking analysis demonstrated that these congeners occupy the colchicine binding pocket of the tubulin.

Moreover, the radioligand competition binding assay also tests whether these fragments occupy the orthosteric ligand binding pocket of the receptor.

Figure 1 Compounds 1 and 2 fitted into the binding pocket of the CB2R receptor model.

This nest sits adjacent to the cGMP binding pocket of the B-site.

The compounds were initially docked into the binding pocket of the homology model of 5-HT3 receptor using GOLD program.

For each binding pocket of the TTR tetramer, the resulting difference Fourier maps revealed two ligand-binding conformations.

This result signifies better conjugation of inhibitor to the binding pocket of the receptor.

Docking of ADP was focused to the binding pocket of the channel.