Sentence examples for binding pocket of an from inspiring English sources

The molecular basis of spectral sensitivity depends on interactions between amino acids within the binding pocket of an opsin protein and its associated light-sensitive chromophore.

Absorption of a photon of light by the chromophore located in the retinal binding pocket of an opsin causes its photoisomerisation from the 11- cis to an all- trans conformation.

In principle, the substrate binding pocket of an enzyme has to have certain amount of plasticity and even if the stereochemistry of a couple of residues is conserved, possible structural changes due to the plasticity associated with other residues can not be ruled out.

The compounds strongly bound to the hydrophobic binding pocket of a-FABP, while showed significantly lower binding affinities to the closely related homologue protein h-FABP.

Dock score which is actually the strength of the non-covalent interactions among multiple molecules within the binding pocket of a target protein.

The binding pocket of a protein is characterized using the distance dependent, knowledge-based pair potentials of the DrugScore scoring function [2] in combination with multiple ligand atom probes.

Site-directed mutagenesis revealed that an arginine side-chain located in the deep binding pocket of a monoclonal antibody (4D5) is essential for binding the neutral polynuclear aromatic hydrocarbon benzo[a]pyrene.

This work provides clues toward uncovering how specificity is achieved within the binding pocket of a polyspecific transporter that may open new possibilities as to how these transporters can be manipulated to bind a designed set of drugs.

In this study, a genetically encoded whole-cell biosensor specifically responding to shikimic acid has been developed by screening a site-saturation mutagenesis library of the binding pocket of a uric acid-responsive regulatory protein.

Structure-based approaches, like DOCK [3, 4] or PLANTS [5], try to dock the ligand into the binding pocket of a target protein, which requires X-ray diffraction or nuclear magnetic resonance spectroscopy experiments to obtain three-dimensional coordinates of the protein structure.

In a first in silico test, we show that by simultaneously optimizing the sequence and structure of three to nine residue peptide extensions starting from short (1 6 residue) peptide stubs in the binding pocket of a peptide binding protein, the approach can recover both the conformations and the sequences of known binding peptides.