Sentence examples for binding pocket occupied by from inspiring English sources

Three secondary structural elements (α-helix residues Leu9-Gly16 and loop residues Gln48-Leu53 Thr74-Lys79ySI3; Finure SI3 in the Supporting Information), located at the acyl-binding site region of the active site, shift to expand the binding pocket occupied by the long UDO-CoA aliphatic chain.

Notably, the thiohydantoin B-ring prevents the compound from accessing the 'H12 pocket' occupied by bicalutamide.

Further, in the Ca2 +-free condition, co-expressed normal- or super-inhibitory PLB mutant with either engineered N30C or V49C residue cross-linked to Lys328 or V89C of SER-20G-PLB at the cytoplasmic or transmembrane domain, respectively, suggesting that these freely diffusing PLB mutants completely replaced the WT-PLB-tether and fit into the binding pocket previously occupied by WT-PLB.

In the APO structure, this binding pocket was occupied by a sulfate ion.

DES contacts two regions of the ligand binding pocket not occupied by E2, located at the 7-α and 11-β positions of E2, and filled by the two ethyl groups of DES.

The clusters of organic solvent probe molecules coincide with pockets occupied by known inhibitors.

The active site pockets lacking a nucleotide are in the closed conformation, whereas the active site pockets occupied by a nucleotide are in the open conformation [ 7].

Residues 85 101 of dimeric NEMO form a flat slit paving way to two broad and extensive IKK-binding pockets; each pocket being occupied by the IKK peptide linker and the NBD.

A proline found in the corresponding position in SF1B enzymes opens a binding pocket to be occupied by a base from the translocating strand (Saikrishnan et al, 2008).

If the peptide in the covalent complex occupies the same binding pocket it occupies in a noncovalent complex with gp120, the conjugate and the noncovalent complexes should have similar ligand binding signatures.

The phenyl moiety of the ligands points towards the complementary side of the binding pocket and occupies approximately the same region as the chloropyridinyl ring of epibatidine.