Sentence examples for binding pocket located at from inspiring English sources
Based upon mutational analysis, GNF-2 was found to bind not to the ATP pocket, but instead to the myristate binding pocket located at the C-terminus of the Abl kinase domain.
Taken together, these results point to a common putative binding pocket located at the concave surface of the LRR, which, however, differs from protein to protein.
Furthermore, an inter-domain motion during ligand binding as well as a ligand binding pocket located at the dimeric interface of form-II AckA has been reported 74 that is very hard to address through in silico docking software.
Structural studies revealed that SCF-I2 intercalates between adjacent blades 5 and 6 of the conserved WD40 β-propeller domain of Cdc4 in such a way that it induces formation of its own binding pocket located at ~25 Å (1 Å=0.1 nm) distance from the substrate-binding site.
In addition, our structure has highlighted the existence of a putative ligand-binding pocket located at the C1 DH domain interface in a location where ligand binding could possibly modulate the exchange activity of Vav1 and its isoforms.
This detergent-binding pocket, located at the juxtaposition of domains I and II of the E protein, is hydrophobic in the pocket [5], [11] and hydrophilic on both sides of the protein surface.
Such attributes have led to the development of small molecule inhibitors of the ATP-binding pocket located at the N-terminus and include derivatives of geldanamycin, radicicol, and purine.
Moreover, as the binding pocket locates within the membrane (Liao et al., 2013; Cao et al., 2013), capsaicin has to interact with lipid molecules first before entering the pocket.
A basic RNA binding pocket is located at the intersection between the two lobes.
In each heterodimer, the binding pocket is located at the ChsH1-ChsH2N interfand and intrudes into ChsH2N.
The homotetrameric TTR transport protein is rich in β-sheet structure, containing two binding pockets for thyroxine located at the interfaces of its four subunits.
