Sentence examples for binding pocket is very from inspiring English sources

As the CDK2 binding pocket is very hydrophobic this generalisation may be sufficient to get a good correlation to experimental binding energy.

The multiple conformations of Thr119 are not observed in the BD dimer, but all other interactions of the inner binding pocket are very similar in both the AC and BD dimers.

Due to the structural constraints placed upon the two cofactors, the geometry of the binding pockets is very highly conserved across the superfamily; the stacked configuration of the cofactors restricts the nicotinamide ring of the pyridine nucleotide from interacting with the isoalloxazine ring from the re-side of FAD [51].

Accordingly, the positioning of E4 in the ligand-binding pocket is very similar to that of E2, leading to a positioning of helix 12 and AF-2 availability that are nearly identical to that elicited by E2.

However, the overall target structures, especially ligand binding pockets, were very similar (Cα RMSD 2.56Å for PDB id 1YV5 and 1RQI) because they shared the same PFAM domain: polyprenyl synthetase (PF00348).

The S3 binding pocket is also well-defined, whereas the S4 pocket is very large and can tolerate a range of capping groups that are likely to contribute to potency by picking up further hydrophobic interactions.

The binding pocket is not in very close contact with the dimerization interface and only a few side chains project into the joint neighborhood.

Finally, ChNPS2 module 3, which 3D models show has a very crowded and small binding pocket is expected to bind to GLY (Table 2, Fig. 4, Fig. 7D).

In addition, targeting allosteric binding sites that are located outside the conserved ATP binding pocket is an emerging strategy that has generated very selective inhibitors [22,23].

The binding pocket is indicated as an exclusion surface.

The positively charged binding pocket is not big enough for ANP binding.