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The enhanced information content of both the buriedness and the shape of a predicted binding pocket is summarized in a shape descriptor.
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The binding pocket is indicated as an exclusion surface.
The positively charged binding pocket is not big enough for ANP binding.
Moreover, a new binding pocket is also explored.
Replacement of water from the uncomplexed binding pocket is assumed to be entropically favorable.
Docked ligand conformation, is presented with sticks and the binding pocket is shown as surface.
The negatively charged binding pocket is not big enough for ATP (Fig. 2B).
A basic RNA binding pocket is located at the intersection between the two lobes.
The volume of the binding pocket is 495 Å.
Four binding pockets are marked as A, B, C, and D. Another binding pocket is marked as LBD.
Then, a binding pocket was generated.
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