Sentence examples for binding pocket is required from inspiring English sources

A second RB mutant (RBΔLXCXE) confirmed that the LXCXE binding pocket is required for the association of RB with Brm1 (Trouche et al., 1997).

Mutation of loop residues ∼10 Å from the active site and mutation of residues directly within the trypsin binding pocket were required to change the substrate specificity of trypsin to that of chymotrypsin.

Because the RB-KN double mutant is defective in transcription repression, we can conclude that an intact LxCxE-binding pocket is required for RB-K to repress transcription.

The observation that bulky lipids such as DHPE inhibit both Raf-1 and kinase association with RKIP suggests that interaction with residues in the vicinity of the pocket rather than binding within the pocket is required for these protein-protein interactions.

Collectively, these data suggest that the involvement of acidic residues E57 and E58 in the QacR multidrug binding pocket is not absolutely required for the neutralization or binding affinity of either cationic drug Be or Dq.

The refined protein models show that besides the active-site residues Ser107, Tyr136 and Lys140, whose mutations impair the overall enzymatic activity and may affect the coenzyme binding mode, side-chains capable of proton exchange, located around the expected substrate (GDP-4-keto-6-deoxy-d-mannose) binding pocket, are selectively required during the epimerization and reduction steps.

Of these 19 genes, there are two type 1 NLPs and 17 type 1a NLPs, which are distinguished based on substitutions in the cation binding pocket that is required for induction of necrosis by cytotoxic NLPs [ 54].

Interestingly, the binding pocket is pre-existing, and docking of the molecules required only small adjustments to the side chains of protein residues.

The binding pocket is indicated as an exclusion surface.

The positively charged binding pocket is not big enough for ANP binding.

Moreover, a new binding pocket is also explored.