Sentence examples for binding pocket is involved from inspiring English sources
The central β-hairpin region of IZUMO1 provides the main platform for JUNO binding, while the surface located behind the putative JUNO ligand binding pocket is involved in IZUMO1 binding.
Comparison of the PDZ1 LPA2 structure to the structure of PDZ1 in complex with a different peptide provides insights into the diverse nature of PDZ1 substrate recognition and suggests that the conformational flexibility in the ligand binding pocket is involved in determining the broad substrate specificity of PDZ1.
Although it is predicted that amino acid residues in the binding pocket are involved in selectivity, the catalytic efficiency could also be affected by the tertiary structure and proteinogenic surrounding area of the adenylation domain [ 63].
Alternatively, as PfRh5 functions in complex with PfRipr and at least one further parasite protein (Chen et al., 2011), if this pocket is involved in binding these partner/s, a small molecule targeting this pocket may likewise interfere with the complex formation and therefore ultimately with its function.
25 To test whether the hydrophobic pocket is involved in peptide binding the assay was performed for both wild-type PBD and a double mutant (Y417A/Y421A), designed to diminish binding to the hydrophobic pocket.
It has also been observed that the E7 NH2-terminal region upstream of the LXCXE pocket, is involved in the degradation of the pRb family of proteins, even though it is not involved in their binding to E7 [ 36].
Competition studies and X-ray crystallographic studies suggest that two large pockets are involved in at least some of the binding [ 10].
Since the Synapsin I ATP binding pocket is localized in the synapsin domain primarily involved in actin binding [69], [72], we investigated whether staurosporine binding is able to affect the synapsin I-actin interaction.
Moreover, a new binding pocket is also explored.
The binding pocket is indicated as an exclusion surface.
The positively charged binding pocket is not big enough for ANP binding.
