Sentence examples for binding pocket is conserved from inspiring English sources

Especially the position of the green colored basic aromatic ring deep in the binding pocket is conserved for the three structures.

This demonstrates that although the nucleotide binding pocket is conserved among the kinase superfamily, their functional roles may not be conserved.

8 11 In particular, aromatic residues that form the binding pocket are conserved between AChBPs and nAChRs, and AChBPs bind several reference nicotinic receptor ligands such as nicotine, epibatidine and lobeline.

Five aromatic residues involved in the formation of the trimethylated lysine binding pocket are conserved in MRG701CD and MRG1CD.

The Asp-His dyad that is part of the catalytic core structure as well as most of the residues that constitute the substrate binding pocket are conserved in tsetse 5'Nuc (respectively His124 and Asp127 and Arg354, Arg358, Arg402, Phe421 and Phe505).

The observation that the SERCA Ca2+-ATPase inhibitor CPA caused a disruption of Na+ regulation might be accounted for by the CPA binding pocket being conserved in PfATP4, though the possibility that the increase in [Na+]i is secondary to a CPA-induced increase in [Ca2+]i cannot be excluded.

The biotin-binding pocket is conserved in BirA variants from different organisms and is lined with residues from L4 (G68, G68 and W74) and β7 (G154 and G156).

Although most of the residues that form the binding pockets are conserved in rat ficolin-A, serine residues in site S2 of human L-ficolin, which form hydrogen bonds via their hydroxyl groups to sugar ligands are replaced by more bulky threonine and asparagine residues, which might exclude certain ligands [ 14].

To determine if the function of the small molecule binding pocket was conserved, we examined the effects of mutations in the yeast Edc3 protein.

The vast majority of reported inhibitors target the ATP binding site but because the ATP binding pocket is highly conserved among the human protein kinase, there can be cross-reactivity with a number of other kinases.

Once established, a SLiM binding pocket is generally conserved over large evolutionary distances as the motif partners constrain the pocket (unless the domain duplicates).