Sentence examples for binding pocket indicates that from inspiring English sources

The size of the substrate binding pocket indicates that one glucose residue is added to the polysaccharide at a time, and indeed the narrow dimensions of the channel support the proposal that it would also only be possible to translocate the chain one residue at a time [ 32 ].

However, the current docking methods could not determine the orientation of ztz240 entering into the binding pocket, indicating that either end may enter into the pocket first (Supplementary information, Figure S4A).

Analysis of other proteins with large binding pockets indicated that the influence of this process varies greatly, dependent on ligand and protein target.

The HA protein contained E190, R220, G225, Q226, and G228 (H3 numbering) residues at the receptor-binding pockets, indicating that the virus preferentially binds to the sialic acid-2,3-NeuAcGal of the avian-like receptor (9 ).

In addition, comparative analysis of the interaction between genistein and the residues that line the ligand binding pocket clearly indicates that the substitution of human ERβ Met 336 by Leu (at position 354 and 369 in zebrafish ERβ−A and ERβ−B, respectively) is likely to decrease the affinity of zebrafish ERβs for genistein as compared to human ERβ (Figure 6B).

This indicates that (as expected) denaturing sample preparation and SDS-PAGE disintegrates the hapten binding pocket and hence separates antibody and payload.

DFT-calculations of a meaningful part of the binding pocket (TPSS-D/SVP) indicated that an exchange of chlorine by bromine and iodine could be useful for the strength of the halogen bond (b+c).

This is consistent with previously published data from [H]granisetron binding studies, and indicates that palonosetron binds in this pocket.

The structure of the binding sites indicates that lipid ligands are anchored within them with their hydrophobic tails oriented towards the core of the protein and their polar headgroups bound to charged sidechains at the mouth of the pockets.

The binding pocket is indicated as an exclusion surface.

Another possibility is that the ideal binding location of flucloxacillin is located in a different region of the binding pocket (as indicated by superimposition).