Sentence examples for binding pocket in which from inspiring English sources

Importantly, WDR5 also binds to H3 itself [ 16, 23], recognizing Arg via the same binding pocket in which the MLL WIN peptides bind [ 21, 22].

The permanganate sensitivity of the T+2 base in the wild type Tn10 transpososome indicates that the binding pocket in which the flipped base is putatively held is more accessible than the equivalent region in the Tn5 transposase.

A279 is located in the binding pocket in which residues E273, N274, D276, I277, play important roles (Husain et al., 2011).

The results revealed a preferred ligand-binding pocket in H4R, which would not have been identified using an unrefined homology model of the protein.

Moreover, we recently used molecular docking to find the role of celastrol's carboxyl group in HSP90 binding, the result indicating a novel binding pocket in HSP90 dimers for celastrol in which the carboxyl group formed two salt bonds with HSP90's residues (these results will be published in another paper).

Notably, quercetin was found to bind inside a rather deep binding pocket in both COX I and II, which is immediately next to hematin.

There is also a neat demonstration of a non-polar binding pocket in crystallographic analysis of SAA3, which is shown directly to form a tetramer through crosslinking studies.

Truncation provides the advantage of not disrupting the first layer of recognition of the protein, thus keeping intact the original binding pocket, in contrast to site-directed mutagenesis, which introduces a different amino acid.

The rationale here was that adding an average value and standard deviation of for example Z1 would provide an average lipophilicity value for a binding pocket (in case of the GPCRs for instance), which could add information.

The benzyl group of 37 occupies a hydrophobic binding pocket in FIH close to the Fe(II) binding site which is absent in the PHDs.

In addition to binding Mdc1, the FHA domain of Nbs1 contains a binding pocket, which in S. pombe is known to interact with phosphorylated residues on Ctp1 to recruit it to the break (Lloyd et al. 2009; Williams et al. 2009).