Sentence examples for binding pocket in the from inspiring English sources
Validation of docking protocol and the size as well as center of the coordinates of the grid was carried out in order to ensure that ligands bind to the binding pocket in the correct conformation.
The TTR∶15 and TTR∶11 crystal structure reveals that 15 binds to the hormone binding pocket in the reverse binding mode and 11 bind in the forward binding mode with an orientation similar to the one obtained through the Goldscore algorithm.
In previous studies, all peptides were assumed to bind to the SH3 binding pocket in the canonical binding mode.
Previous X-ray crystallographic studies of similar ketolides, TEL and CEM101, show these macrolides bind to the macrolide binding pocket in the upper portion of the ribosomal exit tunnel, adjacent to the L22 and L4 constriction site.
Binding of the N-terminal myristate moiety to a unique binding pocket in the c-Abl kinase domain was found to be critical for autoinhibition (Hantschel et al., 2003, Nagar et al., 2003).
They found a binding pocket in the midst of the protein where there is room for the anesthetic to sit.
It has been shown that geldanamycin directly binds to the ATP-binding pocket in the N-terminal domain of Hsp90 [10] [10] and blocks the binding of nucleotides to Hsp90.
Hence, FGFR inhibitors are explored in therapeutics with early candidates developed as competitors for the ATP-binding pocket in the kinase domain.
Molecular dynamics simulation of biotin RNA aptamer in absence of its ligand, as well as semiempirical quantum-chemical calculations of its biotin-binding pocket in the presence of biotin have been performed.
Unlike the rest of the TetR regulators, CmeR has a large center-to-center distance (54 Å) between two N termini of the dimer, and a large flexible ligand-binding pocket in the C-terminal domain.
