Sentence examples for binding pocket identified by from inspiring English sources

Although the binding mode of ZM241385 – the synthetic antagonist co-crystallyzed with the A2A receptor – shows some dissimilarities when compared to carazolol and retinal, the binding pocket identified by our key positions matches that indicated by the crystal structure (Tables 2 4) The natural ligands of class A GPCRs bind extracellularly to large soluble N-terminal ectodomains, i.e. the GPHRs.

The deleted sequence comprises half of the active site binding pocket, identified by the citrate molecule shown in red.

The deleted sequence comprises half of the active site binding pocket, identified by the dipyrromethane cofactor shown in red.

Homology modeling produced a model of the K2P channel that revealed a putative anesthetic-binding pocket identified by the convergence of amino acid residues known to modulate anesthetic activity.

The putative binding pocket identified here, however, might already allow identifying improved Sirtuin inhibitors by screening of larger virtual libraries with more drug-like compounds, even before the anxiously awaited structural information on Sirtuin inhibitor complexes become available.

Structural analysis of the binding pocket identifies important intermolecular contacts that mediate binding.

This crevice corresponds to the urate-binding pocket identified in HucR and PecS.

In addition, the ligand-binding pockets identified a continuous region of hotspots suitable for drug design.

Three amino acid substitutions (Asn89His, Gln153Glu, and Leu205Arg), two of them are near the active site and substrate binding pocket, were identified by sequencing the genes encoding this evolved enzyme.

In this case a set of 3D conformations for the best 2D hits is generated and analogs optimally fitting the binding pocket are identified by overlap with the query ligand and by optimizing interactions with the protein.

The catalytic and binding pocket residues identified by our structure-based search were also found to be evolutionarily conserved.