Sentence examples for binding pocket has been from inspiring English sources

A docking study on the μ-opioid receptor binding pocket has been carried out for ligands 3 11.

For example, in GAPDH, nitrosylation of C152, which is in the NAD binding pocket, has been shown to abolish the catalytic activity of GAPDH by recruiting the E3-ubiquitin-ligase Siah1 [45], [45].

More recently, a model of STA-21 interaction with the Stat3 SH2 pY-peptide binding pocket has been proposed, which featured the 1-oxygen of STA-21 binding to the side chain ammonium hydrogen of R609 within the pY-residue binding site.

The S2 binding pocket has been equated with the MAT allosteric inhibitor binding site; alternatively, these sites may be nonidentical, or multiple allosteric sites may exist.

Putative receptor binding domain of GP1, key residues involved in GP1 protein folding or structure and a putative receptor binding pocket has been proposed and mapped to the N-terminal 150 amino acids of GP1 (33-185 residues).

The mechanism of CYP activation or inhibition by PGRMC1 is highly debatable; however, it is conceivable that it may involve drug delivery or sequestration, as a hydrophobic binding pocket has been identified on PGRMC1.

Docking experiments of compounds 2c, 3b, 3h, 3j, and 3k into COX-2 binding pocket have been conducted, where strong binding interactions have been identified and effective overall docking scores have been recorded.

This Manyanisimilarsystemse same principle as our proposed mechanism: Mg1 2+ coordinates the nucleophile and Mg2 2+ coordinates the leaving oxygen atom (O3′).

The aromatic residues in the binding pocket have been replaced by aliphatic residues, suggesting a likely aliphatic scaffold of the substrate unlike auxin (not shown).

Two spatial clusters of silencing mutations flanking the allosteric binding pocket have been described in [ 10].

Whilst all the homology-modelled sheep antibodies possess pocket-like binding sites with various shapes and sizes (Fig.  2), the development of more compact binding pockets has been attributed to closure of the VL-VH interface of the anti-hapten antibodies and improved binding sensitivities [ 28].