Sentence examples for binding pocket from the from inspiring English sources

Structural analysis combined with molecular dynamics identified a basis for ligand access to the LPA1 binding pocket from the extracellular space contrasting with the proposed access for the sphingosine 1-phosphate receptor.

The most notable difference for these compounds was the observance that docked abacavir in the absence of P2 or P3 would rotate 180° placing the hydroxyl group and cyclopropyl group at opposite ends of the binding pocket from the native crystal.

Interestingly, this DmX receptor has partially diverged in its ligand binding pocket from the metabotropic glutamate receptor family and is not related to the Gr family.

Regardless, the hairpin may play a role in shielding the substrate-binding pocket from the surrounding solvent in both enzymes.

(B ) In the forward evolution, selection for arylesterase activity leads to several changes in the binding pocket from wt PTE to AE (PDB ID: 4PCN).

The same set of drugs was superimposed in the HLA-B*57 01 HLA-B*57 01ket from XP + P2 (Additional file 1: Figure 4A) and XP + P3 (Additional file 1: Figure 5A) screening.

An ordered sequential mechanism with acetyl-CoA binding first suggests that acetyl-CoA binding drives a conformational change to convert the amine binding pocket from a low-affinity state to a high-affinity state.

In addition, the synergistic effect of acetyl-CoA binding to convert the amine binding pocket from a low-affinity state to a high-affinity state means that specific amino acids important for acetyl-CoA binding can also have a dramatic effect on amine binding.

The binding sites for PAA and diltiazem share common amino acid residues but it is assumed that the two classes of drug access their binding pockets from different sides of the membrane.

Another factor allowing for inhibition of SULT1E1 by BFRs is the expanse of the substrate binding pocket away from the catalytic site.

In the gene pool identified, the functional basis for essentiality has been addressed by studying residue level conservation and the sub-structure at the ligand binding pockets, from which essential amino acid residues in that pocket have also been identified.