Sentence examples for binding pocket formed by from inspiring English sources

The proposed mode of inhibition includes a trapping of clathrochelate inhibitor molecule by the binding pocket formed by three interconnected macromolecules of the transcription complex.

There is evidence that MMP-2 has a channel-like S1' cavity and MMP-9 has a pocket-like S1' cavity with a floorboard [1, 12, 30] and the S1' is a substrate binding pocket, formed by two subdomains.

Drawn with Discovery Studio 3 (Accelerys) [23, 35]. Figure 17c shows the propanol molecule in Insugen (I) lying in a binding pocket formed by rigid body movement of the first helix of chain C with respect to the structure of Baker et al. [1] (PDB 4INS).

And for the case of NDM-1/Meropenem complex, the antibiotic drug was hydrolyzed in a binding pocket formed by twelve residues.

The fluorenyl ring moiety of the inhibitor is located at the outer binding pocket formed by residues Ala108, Lys15, Leu17, Thr106, and Val121 of both TTR subunits.

(B ) The binding pocket formed by hydrophobic residues (orange) that accommodate the crotonyl lysine.

Its tertiary structure has recently been elucidated for TRIM21, revealing two binding pockets formed by six variable loops [ 16].

No higher aggregates or complexes containing one or three zinc ions were observed, thereby suggesting that transition metal ions are solely coordinated in the binding pockets formed by the TACN nitrogen atoms and the phenolic hydroxyl group.

The NLS-binding domain of Impα is formed from 10 armadillo (ARM) repeats, and contains two binding pockets formed by repeats 2 4 and 7 9, known as the major and minor binding sites, respectively (Conti et al, 1998; Conti and Kuriyan, 2000).

Such studies broadly suggest a TAS2R ligand-binding pocket formed by several transmembrane (TM) domains (particularly TM3, TM5, TM6, and TM719).

There is a potential heme/steroid binding pocket formed between two helices α2 and α3.