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The binding pocket flanked by YscN residues Y325 and T398 is occupied by ring structures of the small molecules and the binding interactions reflect potential π-π stacking with the tyrosine ring.
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PYR/PYL/RCARs contain an internal ligand-binding pocket flanked by two conserved loops, the 'Pro-cap/gate' and the 'Leu-lock/latch' (Melcher et al., 2009; Nishimura et al., 2009; Santiago et al., 2009a).
This binding pocket is flanked by several polar residues (Fig. 1) whose contribution to bacterial ligand binding is apparent and variable (Virji et al., 1999; 2000).
Previous structural analysis has highlighted that Parkin contains a putative phospho-Ser-binding pocket that we term "Pocket 1" flanked by residues Lys161 (K161), Arg163 (R163) and Lys211 (K211) that lie within the RING0 domain [ 13] (Fig 2A).
The apo ABA receptor contains an open ligand-binding pocket that is flanked by two highly conserved loops that serve as a gate and latch.
In addition, these binding sites are flanked by high peaks of H3.3 dissociation and enrichment levels.
DYNLL-binding motifs are often flanked by coiled coil or other dimerization domains.
They are located in and near the binding pocket facilitated by crystal packing effects.
These drastic changes in measured TIF likely occur from slight changes in the binding pocket caused by different co-binding peptides P1, P2, and P3.
Especially, we observe a potential substrate binding pocket surrounded by hydrophobic residues upon NADPH binding and present evidences that this pocket is essential for BdcA binding NADPH and exerting its biological functions.
(B ) The binding pocket formed by hydrophobic residues (orange) that accommodate the crotonyl lysine.
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