Sentence examples for binding pocket could be from inspiring English sources

In this way, binding pocket could be defined consistently across the same structural ensemble, varying in conformation but not in composition.

In addition, many drug pairs with potential similar binding pockets could be discovered by the domain matching information.

By docking of the 2PET model substrate, the substrate-binding pocket could be identified as a large groove on the surface of Tcur1278 and Tcur0390 (Figure 4C-F).

When the scaffold is tethered at an appropriate position, a molecule that potentially interacts with the GABA-binding pocket could be a potent ligand, which opens a door for future PTL design.

To discover new KCNQ2 activators and to further verify the possible activator-binding pocket, we carried out a structure-based virtual screen targeting the identified pocket, guided by the notion that if the identified binding pocket is reasonable, novel activators recognizing the identified ztz240-binding pocket could be discovered.

Although the active site of phosphoglucomutase is highly conserved from parasite to human, initial calculations show that a ligand binding pocket could exist near the hinge region, which is unique to the parasite.

Residues 305 314 on the surface of the first subunit are not in a position to interact directly with the binding pocket, but could be involved in mediating interactions between the two subunits.

Of particular interest is the category of temperature-sensitive mutations in the Rb pocket domain (ΔAsn480, Arg661Trp, Cys712Arg) whose 'reversible fluctuations' in a threshold level of Rb pocket-binding activity could be responsible for their characteristic low penetrance (Otterson et al. 1999).

This is indicative of a change in binding mode or could be due to the phenyl ring in C12M02 occupying a new high affinity binding pocket.

This binding could be inhibited by heparin.

Replacement of water from the uncomplexed binding pocket is assumed to be entropically favorable.