Sentence examples for binding pocket compared with from inspiring English sources

Neonicotinoids with an electronegative pharmacophore are embraced by a reversed position in the binding pocket compared with a nicotinoid cationic functionality.

Zebrafish PXR showed the most constrained pharmacophore based on the 16 ligands, suggesting a small binding pocket compared with the other PXRs, consisting of 3 hydrophobes, 1 hydrogen bond acceptor, and excluded volumes.

The 19F NMR screening yielded a high primary hit rate of binders to the ERK2 ATP-binding pocket compared with the rate for the SPR screening.

The crystal structure of FED1 shows a binding mode similar to EPZ004777, with the tert-butyl phenyl urea motif further extending the binding pocket compared to SAM.

In Sirt3, the hydrophobic residues are moved toward each other, closing the binding pocket compared to Sirt2.

An intriguing result was the differences in binding profile (monophasic compared with biphasic) and affinity of the cation-binding pocket detected by Tb3+- and Ca2+-binding assays.

We checked the position of all the conserved residues in the ATP-binding pocket and compared them with corresponding residues in active PKA and inactive RSK1 or MSK1.

But that's just pocket change compared with Bergdorf's.

In L3MBTL1, the corresponding residues (Met357, Asp383 and Asp415) can also assist in peptide binding, however, the negatively charged area around the methyl-lysine-binding pocket is less extended compared with dSfmbt, which might explain the lower binding affinity.

Again, the stronger binding of compound 4 compared with 3 suggests the greater ability of the more rigid ring system to bind in the tricyclic pocket of TryR.

Further differences of the quadrupole structure will contribute to specific local van der Waals interactions in the binding pocket and with the Aux/IAA degron (compare weak (Low Efficiency) and strong (High Efficiency) ligands in Figure 7).