Sentence examples for binding pocket compared to from inspiring English sources

In Sirt3, the hydrophobic residues are moved toward each other, closing the binding pocket compared to Sirt2.

Overall, these data support the initial hypothesis that the [Y]-AII superior selectivity to AT2R is based on a more hydrophobic and compact binding pocket (compared to AT1R).

The crystal structure of FED1 shows a binding mode similar to EPZ004777, with the tert-butyl phenyl urea motif further extending the binding pocket compared to SAM.

The usage of an increased number of 30 scanning directions provides a finer resolution of the identified binding pockets compared to other implementations.

However, Nutlin-3 cannot bind to MDMX, most likely due to the presence of various sequence differences in its p53-binding pocket compared to MDM2 [27], [27].

Neonicotinoids with an electronegative pharmacophore are embraced by a reversed position in the binding pocket compared with a nicotinoid cationic functionality.

Zebrafish PXR showed the most constrained pharmacophore based on the 16 ligands, suggesting a small binding pocket compared with the other PXRs, consisting of 3 hydrophobes, 1 hydrogen bond acceptor, and excluded volumes.

The 19F NMR screening yielded a high primary hit rate of binders to the ERK2 ATP-binding pocket compared with the rate for the SPR screening.

An interesting feature of the TPT molecule concerns the mobility of the di-methyl-amino group on the A ring, that is altered in the enzyme-DNA binding pocket, as compared to the simulation of TPT in water solution [24].

In part, this may be due to the relatively closed conformation of the binding pocket when compared to crystal structures of related PWWP domains bound to methylated peptides (Additional file 1: Figure S2c).

To further understand the basis of cladosporin selectivity, the amino acid residues of the ATP-binding pocket were compared to those in Krs1 of other species.