Sentence examples for binding pocket by a from inspiring English sources

Characterization of the binding pocket by a grid-based surface calculation of the docking model suggested that a larger hydrophobic body plus a polar tail would improve interaction between the ligand and the receptor.

Characterization of the binding pocket by a grid-based surface calculation of the docking model revealed a large unfilled hydrophobic region near the central phenyl ring, suggesting that compounds with larger hydrophobic groups in this region would improve binding.

Thus, occupation of the polyphosphate binding pocket by a substituted phenyl is another commonly observed feature among ROCK inhibitors.

In AKT3, substitution of a threonine residue for serine at position 203 (equivalent to AKT1 Ser 205) may affect the ability of Inhibitor VIII to hydrogen bond to the protein and also alters the binding pocket by introducing an additional methyl group.

Auxin is trapped in the TIR1 auxin-binding pocket by an interacting Aux/IAA protein [ 22].

It was hypothesized that blocking of the FimH binding pocket by preferential binding to a soluble mannose residue would reduce the binding to uroplakins on the epithelial cell surface of the bladder.

Docking models are frequently inaccurate due to many simplifications used in their implementation, whereas MD simulations can provide considerably more accurate data as to the location of a ligand in a binding pocket by refining initial docking structures (22, 23).

Payloads for hapten-positioned disulfide coupling shall bind to the antibody binding pocket by the hapten, to be positioned for subsequent site-directed conjugation.

Binding in this manner increased the volume of the binding pocket by 40% while maintaining helix 12 in a position consistent with agonist binding.

In the present study we find that disruption of the binding pocket by mutating three key residues has a similar effect on the ability of PDI to exchange disulfides with Ero1α to reform the regulatory disulfides.

For the first time in a FimH structure [47], [52], [53], a nickel ion was observed, interlinked with the mannose binding pocket by Asp47 (Figure 2).