Sentence examples for binding pocket based on from inspiring English sources
The pharmacophore model was then created for the rigid part of the binding pocket based on high- propensity peaks of these maps.
Computational modeling highlighted that key to high enantioselectivity is the discrimination of the R and S substrates by the sole hydrophobic binding pocket based on their size and bulkiness.
Almost all inhibitors target the ATP binding pocket based on a simple principle: if ATP cannot be bound, phosphorylation cannot occur.
Six halogen binding pockets (HBP1, HBP2', HBP3, HBP2', HBP3 and HBP3') were also defined within each hormone binding pocket based on the positions of the halogen atoms of T4 in the TTR∶T4 crystal structure, Figure 2b [22] [22].
Such stabilizing interactions might derive from direct contacts to residues in helices α1, α2, or α6 that are predicted to line the binding pocket based on the HucR structure; in addition to W11 from α1, candidate residues include a His from α6 and a Gln from α2.
Hence, we developed novel binding pocket descriptors based on 3D molecular interaction fields.
We previously reported that FK228 binds to the ATP-binding pocket of p110α based on a study with a docking model.
The newest version of Surflex-PSIM is able to automatically detect ligand binding pockets and compare them, based on their surface similarity to other binding sites extracted from large protein databases (e.g. PDB).
Additional pockets are based on your preference.
Without exception, the affected residues in the Ts– strains lie within the dimerization interface encompassing the GTP-binding pocket (the G interface), based on the locations of the equivalent (and highly conserved) residues in human septins.
