Sentence examples for binding pocket at the from inspiring English sources
According to accepted theory, an increase in cytosolic Ca2+ concentration causes four calcium ions to bind to calmodulin, which allows calmodulin to enter the binding pocket at the MLCK C-terminus, and thereby, activates MLCK [35].
Both predict the cinnamaldehyde binding pocket at the C terminal region involving the T7 loop of FtsZ.
By deriving a virtual binding pocket at the same time as the relative poses of ligands are identified, the key analogy is that one can treat a computational model of a binding site as one treats a protein binding pocket.
Three classes of positive modulator, the benzamides, the thiadiazides, and the biarylsulfonamides differentially occupy a solvent accessible binding pocket at the interface between the two subunits that form the AMPA receptor ligand-binding pocket.
Another parameter to consider is the size of the binding pocket at the target receptor; searches are usually performed to find fragments that can bind to a small particular area of the binding site at the target receptor, in that case, a user-defined ligand is needed for that purpose.
This result is consistent with previous reports that RB interacts with E2F3 mostly through its E2F-peptide binding pocket at the A/B interface that is inactivated by the K530A mutation.
A virtual screening strategy that included per-residue interaction patterns (footprints) was employed to identify small molecules compatible with putative binding pockets at the internal interface of the NHR helices at the core native viral six-helix bundle.
A comparison shows that the crystal structures of FabG from P. aeruginosa and S. aureus 33) are very similar and that the inhibitor binding pockets at the A/B and C/D interfaces (see below) could potentially also be formed in the S. aureus enzyme.
PAQ acts as a competitive inhibitor of the ATP-binding pocket at the catalytic intracellular tyrosine-kinase (TK) domain of VEGFR-2.
