Sentence examples for binding pocket as the from inspiring English sources

Subsequent base excision presumably facilitates accommodation of the resulting lesion site into the binding pocket, as the enzyme interaction with the THF-containing duplex is characterized by high affinity and a large negative heat capacity change.

With regard to pharmacology, a CNS PET ligand should be potent (Bmax/Kd >10, see section on 'understand the target') and selective towards the target of interest (typically > 30×) and needs to occupy the same binding pocket as the drug molecule to allow competitive blocking and target occupancy measurement.

In order to address the question of where the probe binds to the protein, competitive titrations were carried out to verify whether the probe shares the same binding pocket as the known substrates or products of the kinase, i.e. ATP, ADP or the substrate peptide [8].

Using molecular docking of retinal, a 3 12 Å wide continuous channel through opsin with the retinal binding pocket as the central part was found.

The Sδ and Cε atoms of M561 in FGFR1V561M would cause steric clashes with the phenyl ring and push the ligand away and out from the binding pocket as the major contributing factor to greatly reduced sensitivity to this inhibitor.

Positioning of the splice site is enabled by a conserved guanosine (ΩG) at the 3′-intron exon junction, which occupies the same binding pocket as the exogenous guanosine of the first step.

Forced twisting of the polyene backbone away from its normally planar configuration induced by the binding pocket as well as the electrostatic environment surrounding the chromophore are major factors that influence its absorbance maximum.

Moreover, several residues known to be critical in the caspase-3 catalytic centre and binding pocket, as well as the active-site pentapeptide motif Q172ACRG176 were present in the deduced Lyccasp3.

Accordingly, the orientation of the retinal in its binding pocket, as known from the dark state rhodopsin structure[1], determines its longitudinal orientation during uptake and release.

Modelling of the ECLs suggests that these residues form putative intermolecular salt bridges that stabilize CXCR3 and presumably gate entry of the ligand into the binding pocket as has been previously shown for the β2-adrenoceptor (Wang and Duan, 2009).

Supporting NMR titration data further indicated that this peptide binds with the phosphothreonine in the canonical binding pocket as might be predicted.